Phytochemical and Antioxidant Investigation of the Aerial Parts of Dorema glabrum Fisch. & C. A. Mey
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Abstract:
Dorema glabrum Fisch. & C.A. Mey. (Apiaceae) is a monocarpic perennial plant distributed in southern Caucasus. In Azerbaijan Republic folk medicine, the gum-resin of this species is used as a diuretic and anti-diarrheal agent. It is also traditionally used for the treatment of bronchitis and catarrh. In the present study, chemical constituents of the essential oil and extract of D. glabrum aerial parts were investigated and their free radical scavenging potentials were assessed. GC-MS and GC-FID analyses of the plant essential oil resulted in identifying twenty compounds, out of which elemicin (38.6%) and myristicin (14.3%) were main compounds. Seven compounds including daucosterol (1), chlorogenic acid (2), a mixture of cynarin (3) and 3,5-di-O-caffeoylquinic acid (4), isorhamnetin-3-O-β-D-glucopyranoside (5), isoquercetin (6) and astragalin (7) were also isolated from the ethyl acetate and methanol fractions of D. glabrum aerial parts using different chromatographic methods on silica gel (normal and reversed-phase) and sephadex LH20. Structures of the isolated compounds were elucidated using UV and 1H, 13C-NMR spectra in comparison with those reported in respective published data. Antioxidant activities of the crude extract, fractions and isolated compounds were evaluated using DPPH free radical scavenging assay method. Among the fractions, methanol fraction (IC50= 53.3 ± 4.7 μg ml-1) and among the isolated compounds, caffeoylquinic acid derivatives exhibited the highest free radical scavenging activity (IC50= 2.2-2.6 μg ml-1).
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Phytochemical and Antioxidant Investigation of the Aerial Parts of Dorema glabrum Fisch. & C.A. Mey.
Dorema glabrum Fisch. & C.A. Mey. (Apiaceae) is a monocarpic perennial plant distributed in southern Caucasus. In Azerbaijan Republic folk medicine, the gum-resin of this species is used as a diuretic and anti-diarrheal agent. It is also traditionally used for the treatment of bronchitis and catarrh. In the present study, chemical constituents of the essential oil and extract of D. glabrum aeri...
full textphytochemical and antioxidant investigation of the aerial parts of dorema glabrum fisch. & c. a. mey
dorema glabrum fisch. & c.a. mey. (apiaceae) is a monocarpic perennial plant distributed in southern caucasus. in azerbaijan republic folk medicine, the gum-resin of this species is used as a diuretic and anti-diarrheal agent. it is also traditionally used for the treatment of bronchitis and catarrh. in the present study, chemical constituents of the essential oil and extract of d. glabrum aeri...
full textAzeroside C: a new phloroacetophenone glycoside from the roots of Dorema glabrum Fisch. & C.A. Mey
Background and objectives: Dorema glabrum Fisch. & C.A. Meyfrom Umbelliferae family is a monocarpic species distributed in north-west of Iran, Azerbaijan republic and Armenia. The gum-resin of this species is traditionally used for the treatment of bronchitis, catarrh and diarrhea, as well as for its diuretic properties. Recently, we have reported the isolation of five...
full textFree Radical Scavenging Potential and Essential Oil Composition of the Dorema glabrum Fisch. C.A. Mey Roots from Iran.
INTRODUCTION Dorema glabrum is an endangered species that grow in Transcaucasia and North West of Iran. The plant has extensive uses e.g. as an herbal remedy or food additive in these regions. The chemical composition of hydrodistilled oil of D. glabrum growing in Iran was analyzed by GC-MS for the first time. METHODS The essential oil of air-dried roots was obtained by hydrodistillation usin...
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Journal title
volume 14 issue 3
pages 925- 931
publication date 2015-06-01
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